Candida glabrata Sepsis in an Immunocompetent Individual: A Case Report

Candidemia is a significant source of systemic fungal infections, with Candida glabrata (C. glabrata) becoming prominent in recent decades. We describe a unique case where postoperative urinary retention and C. glabrata UTI led to invasive fungaemia with bladder necrosis. A 37- year-old previously well nulliparous woman underwent an elective diagnostic laparoscopy, hysteroscopy dilation and curettage, and dye studies for investigation of infertility. She re-presented six days post procedure with C. glabrata urosepsis with a subsequent laparoscopy on day 16 revealing fungal plaques in the bladder, and a large necrotic defect in the bladder dome. The patient was managed with bilateral nephrostomies, a pelvic drain and antifungal therapy. Four weeks post-insertion of the nephrostomies, a cystogram revealed spontaneous closure of bladder defect. The nephrostomies were removed and antibiotics and anti-fungal continued for a month until negative urine cultures were attained. The patient was well four months after discharge with mild urinary symptoms. The literature has reported two cases of candida UTIs resulting in bezoars and bladder rupture, occurring only in immunocompromised patients. This case highlights the challenges of C. glabrata sepsis and its potential for severe morbidity in a nonimmunocompromised patient, suggesting the need for guidelines in the early detection and treatment of C. glabrata sepsis.


Lynn Tan, Maya Reddy, Devashana Gupta and Beverley Vollenhoven

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Recommended Conferences

  • 7th Annual Congress & Expo on General Practice and Women’s Healthcare
    July 27-28, 2018 Vancouver, British Columbia, Canada
  • 6th American Gynecological Surgery Conference
    September 28-29, 2018 San Antonio | Texas | USA
  • 5th International Conference on Gynecology and Obstetrics
    October 08-10, 2018 Zurich, Switzerland
Flyer image

Abstracted/Indexed in

  • Index Copernicus
  • Google Scholar
  • CiteFactor
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Geneva Foundation for Medical Education and Research